Monthly Archives: November 2013

Treatment for Anal Fissures

Anal fissures are painful splits in the lining of the anus. This typically occurs with straining and stretching, but can be associated with IBD. Treatment options fall into 3 main categories. 1) Stool softening – High fluid and soluble fibre intake +/- Osmotic laxatives eg. Movicol 2) Muscle relaxants – Diltiazem 2% ointment bd + GTN 0.4% ointment bd (Rectogesic)…

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Tacrolimus in Refractory IBD

Tacrolimus can be used in refractory IBD It is administered orally at a dose of 0.1 mg/kg body weight/day (e.g. 10mg for 100kg man) The dose may need to be adjusted in order to achieve an optimum serum trough levels of 5–10 ng/ml The rule of thirds seems to apply – 1/3 fail and need surgery, 1/3 develop side-effects, and…

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